Additive stabilization of SEI on graphite observed using cryo-electron microscopy

Effects of Displacing Radiation on Graphite Observed Using in Situ Transmission Electron Microscopy Original Citation Effects of Displacing Radiation on Graphite Observed Using in Situ Transmission Electron Microscopy

Graphite is used as a moderator and structural component in the United Kingdom’s fleet of Advanced Gas-Cooled Reactors (AGRs) and features in two Generation IV reactor concepts: the Very High Temperature Reactor (VHTR) and the Molten Salt Reactor (MSR). Under the temperature and neutron irradiation conditions of an AGR, nuclear-grade graphite demonstrates significant changes to it mechanical, t...

Cohomology of Cryo-Electron Microscopy

The goal of cryo-electron microscopy (EM) is to reconstruct the 3-dimensional structure of a molecule from a collection of its 2-dimensional projected images. In this paper, we show that the basic premise of cryo-EM—patching together 2-dimensional projections to reconstruct a 3-dimensional object—is naturally one of Čech cohomology with SO(2)-coefficients. We deduce that every cryoEM reconstruc...

Mathematics for cryo - electron microscopy

Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method for biological macromolecules. Cryo-EM was selected by Nature Methods as Method of the Year 2015, large scale investments in cryo-EM facilities are being made all over the world, and the Nobel Prize in Chemistry 2017 was awarded to Jacques Dubo...

Viewing Angle Classification of Cryo-Electron Microscopy Images Using Eigenvectors

The cryo-electron microscopy (cryo-EM) reconstruction problem is to find the three-dimensional structure of a macromolecule given noisy versions of its two-dimensional projection images at unknown random directions. We introduce a new algorithm for identifying noisy cryo-EM images of nearby viewing angles. This identification is an important first step in three-dimensional structure determinati...

The Development of Cryo-electron Microscopy